12/25/2023 0 Comments Pemsa binder![]() Mizuta R, Devos JM, Narayanan T, Oliva M, Gray M, Webster J, Ling W, Round A, Munnur D, Mossou E, Farahat A, Boykin DW, Wilson WD, Neidle S, Schweins R, et al. Combining 1,3-ditriazolyl-benzene and quinoline to discover a new G-quadruplex interactive small molecule active against cancer stem-like cells. Mendes E, Cadoni E, Carneiro F, Afonso MB, Brito H, Lavrado J, Dos Santos DJVA, Vítor JB, Neidle S, Rodrigues CMP, Paulo A. Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology. Vo T, Oxenford S, Angell R, Marchetti C, Ohnmacht SA, Wilson WD, Neidle S. A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells. PMID 32832034 DOI: 10.1021/Acsmedchemlett.0C00317Īhmed AA, Marchetti C, Ohnmacht SA, Neidle S. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. PMID 33227941 DOI: 10.3390/molecules25225407Īhmed AA, Angell R, Oxenford S, Worthington J, Williams N, Barton N, Fowler TG, O'Flynn DE, Sunose M, McConville M, Vo T, Wilson WD, Karim SA, Morton JP, Neidle S. A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells. Beyond the double helix: DNA structural diversity and the PDB. Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Jhan CR, Satange R, Wang SC, Zeng JY, Horng YC, Jin P, Neidle S, Hou MH. Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids. Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Satange R, Kao SH, Chien CM, Chou SH, Lin CC, Neidle S, Hou MH.
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12/25/2023 0 Comments Magic jellybean keyfinder office 2010This software is very easy to read and you can search product key within the result.įinds Key For : Windows server 2003, Windows server 2008, Windows XP, Windows Vista, Windows 7, Windows 8, Windows 10, MS Office XP, MS Office 2003, MS 2007, MS 2010, MS 2013, Adobe, Cyber link and lot more products. SterJo key finder can display product key for lots of games and software. Product can be copied to or saved to a file.Īnother useful software that is supported to Windows 10 and can find product key for Windows 10.įids key for : Windows server 2003 Windows 2000, Windows XP, Windows Vista, Windows 7, Windows 8, Windows 10, Microsoft Office 2003, MS Office 2007, MS Office 2010, Microsoft Office 2013, most Adobe product etc. This software is portable so that no need of installation. The main drawback of the software is this is not be updated since 2013. You can copy product key to a file or it can be printed.įinds key for : Windows 2000, Windows XP, Windows 2003, Windows 7, Windows Vista, Microsoft Office 2003, 2007, 2010, 2013, XP. You do not need to press any button it displays keys normally. Size of the software is so small that it can be downloaded quickly. This software is portable so that no installation required. Windows 7, Windows 2000, Windows NT Windows server 2008 & 2003, Windows Vista and most applications from Adobe and Microsoft. After installing the app, you can see all the product key list that the app can detect.įinds keys for : It cannot find produxt keys for Windows 10, and Windows 8. Product key finder is a very simple app capable to display product key. You can save keys to a file or can copy to clipboard.įinds keys for : All versions of Windows, Microsoft Office 20, office XP and many non-Microsoft programs. This finder can display product key instantly. ![]() Magical Jelly Bean key finder has multiple product key saving options. In a word it’s not just a key finder it’s a footprint of your computer. The size of the key finder is very small and handy.įinds keys for All version of Windows like Windows 10, Windows 8, Windows 8.1, Windows 7, all versions of MS office, Microsoft enterprise products, product from Adobe, Corel, Nero and keys for lots of popular video game. ![]() It also shows you other computer information like RAM, Motherboard, Processor along with the product key. Belarc Advisorīelarc Advisor is one of the best product key finders. Here we are discussing about some very useful product key finder applications. But if you cannot from there, Product Key Finders are very helpful. Generally, you can get product key on original installation disc. ![]() Product key finder is a free software that helps to show the product key of installed windows software when you are trying to reinstall them and you somehow forgot the unique product key. ![]() This means that for now we have to see how these cards play out in the DirectX 10 world. Indeed while there are a few releases due any day now, it won't be until mid next year that we'll really see how support is shaping up. It's difficult to say for certain at this point how big a step forward DX11 will be for gaming, but Microsoft has at least tried to make it as easy as possible for developers to code for the new API.Įven so, at the time of testing there are no compelling games that really show what DirectX 11 is capable of, or really push this hardware at all. with little to no reason to prefer 10 over 11. While I haven't heard Direct3D 10 called 'buggy', I'd argue Direct3D 11 tends to be just all around better with various minor improvements to the API. It's not immediately obvious why AMD has picked these price points, but just to clarify: the top of the range 5870 is available for £300, the 5850 rolls in at the £200 mark, while the 57 are available for £130 and £100 respectively.Īnnoyingly the 5750 should be a $100 offering, but this hasn't translated well as it crossed the channel.Īll three cards need to be considered in the context of DirectX 11 and the potential it holds. You can target older graphics cards (as far back as Direct3D 9 era) via the use of feature levels while using the Direct3D 11 API, yes. The difference is these have all undergone differing levels of silicon pruning in order to hit certain price points. "Attempt to Run" is also completely greyed out, so i can't do that, either.All three new GPUs use the same 40nm production process and boast the same DX11-supporting engine of the all-singing all-dancing 5870. Restarted PC every time after updating drivers, deleting folders, uninstalling, etc. But my graphics card is 1/4th of the reccomended graphics cards power and I can still run at around 30. In theory the game should start, but it would probably not run very well at all. Uninstalled the entire game, and re-downloaded it. Well, the HD 5450 is a DX11 card, but it is very low-end and below the minimum system requirements for this game. Tried changing the /Games/Age of Empires 3 DE/Logs/PerformanceMetrics/*my PC name.txt* file, which states i have "VideoRAM: 0 MiB", "Video Score: 0" and nothing after "Video Desc:" to have actual values, but the file got automatically overwritten when i launched the game againĬhecked for Windows updates, downloaded and installed what was available What i've done to TRY and fix it (none of it helped):ĭeleted the /users/*my username*/Games/Age of Empires 3 DE folderĭeleted the /steamapps/common/Aoe3DE/Startup folderĬhecked that Directplay was enabled, it was and still isĬhanged Nvidia Control panel setting "OpenGL rendering GPU" from "Auto-select" to "GeForce GTX 980" Your video hardware does not support DirectX 11 which is required for Age of Empires III DE." This computer appears to have a 0 MB video card. "Your video hardware does not support DirectX 11 which is required for Age of Empires III DE.Īge of Empires III DE requires at least a 1 GB video card. Intel Core i7-4970K CPU 4.00 GHz (8 CPUs) Including having launched and ran it perfectly fine back when it released, so it must be an issue introduced with the patches.ĭifference is i'm running it on a desktop and not a laptop, and only have 1 video card. 12/25/2023 0 Comments Google photos app for mac desktop![]() If you want to find out Google Photos vs Backup and Sync, both are actually the same thing. ![]() That is how you use Google Backup and Sync photos on a computer. Wait for the app to upload your photos to Google Photos. Under "Photo & video upload size", select your upload size.
12/24/2023 0 Comments Convert a pdf to keynote![]() Today’s announcement does not affect how we use or share data. We also intend to start trading under the new stock ticker we have reserved, MVRS, on December 1. Starting with our results for the fourth quarter of 2021, we plan to report on two operating segments: Family of Apps and Reality Labs. Our corporate structure is not changing, however, how we report on our financials will. Spark AR Certification & Professional Course Preview.‘Blade & Sorcery: Nomad’ Is Coming to Oculus Quest.How VR Is Changing the Way We Collaborate and Get Things Done.Horizon Home, the Future of Work, Presence Platform, and More.Connect 2021: Our Vision for the Metaverse.You can also learn more about our work over the past several months to develop the Meta brand on our design blog. You can watch the full Connect keynote and learn more about how the metaverse will unlock new opportunities at. We also announced new tools to help people build for the metaverse, including Presence Platform, which will enable new mixed reality experiences on Quest 2, and a $150-million investment in immersive learning to train the next generation of creators. This year’s virtual event explored what experiences in the metaverse could feel like over the next decade - from social connection, to entertainment, gaming, fitness, work, education and commerce. Our annual Connect conference brings together augmented and virtual reality developers, content creators, marketers and others to celebrate the industry’s momentum and growth. Mark shared more about this vision in a founder’s letter. It’s the next evolution in a long line of social technologies, and it’s ushering in a new chapter for our company. It will let you share immersive experiences with other people even when you can’t be together - and do things together you couldn’t do in the physical world. The metaverse will feel like a hybrid of today’s online social experiences, sometimes expanded into three dimensions or projected into the physical world. Meta’s focus will be to bring the metaverse to life and help people connect, find communities and grow businesses. Today at Connect 2021, CEO Mark Zuckerberg introduced Meta, which brings together our apps and technologies under one new company brand. Herrscher Of The Void ( Honkai Impact 3rd).Skimming users and the Ways ( The Wheel of Time).Flying Thunder God Technique users ( Naruto).Hong Shen-long ( Daybreak!! Men's Private School: Young Men, Embrace the Great Death).Awaki Musujime ( A Certain Magical Index).Kuroko Shirai ( A Certain Magical Index/A Certain Scientific Railgun).Only high-level users can travel through timelines or alternate realities.Dependent on the users, sometimes subspace may be turbulent and require stabilization before travel.Can teleport to the wrong location if not focused.May require a good amount of energy to perform.Tearing through subspace rifts can cause instability in space.This is especially troublesome as speed of teleportation may be too fast to control. Telefrag, which is entering the spatial location that is preoccupied by existing matter, can cause lethal backfiring.High-level users can teleport parts of an opponent away, such as removing a limb, internal organs, or even a head, instantly killing them.Teleport a massive object above the target, letting it crash down to crush the opponent to death.Teleport an opponent to the front to intercept an incoming attack, gaining a shield and causing the opponent's attempt to backfire at the same time.Teleport an attack back at the opponent.More advanced users can teleport even air or water molecules in the air when more physical ammunition is lacking.Teleport objects into a target, causing telefrag, punching holes or bisecting the opponent.Teleport to other timelines or dimensions using subspace as an intermediate stop.Teleport objects to another location, creating instant mailing.Teleport to incredible distances instantaneously.Spatial Mimicry: Teleport only parts of the user to through the space-time continuum, leaving them to occupying the three-dimensional space without physical form. ![]() Spatial Attack: Teleport physical matter into an opponent, causing unstoppable damage.Hyperspace Travel: Travel faster then light.Interstellar Travel: Travel interstellar distances.Can be used both offensively and defensively. ![]()
If this didn’t work, you should also try to unplug & re-plug the computer. Then, you should plug the USB stick into a different computer and see whether it can be detected or not. This will fail if the USB port is faulty, damaged, or dead your USB drive still can’t be recognized. You should unplug your USB stick from the current USB port and try plugging it into a different port on the computer. Method 3: Plug It into Another USB Port or Computer Well, what if you find your flash drive not showing up in disk management? Please read the following content to know how to get a computer to recognize your USB flash drive. MiniTool Partition Wizard can also help you Change Drive Letter and Create Partition.
12/24/2023 0 Comments Weclean laundry![]() Once the economy reopens, WeClean targets to sign up one franchisee a month. He added that the franchise idea has already generated over 120 leads. ![]() And as we launch our mobile app, we are eyeing to be able to have between 25,000 to 30,000 downloads in Metro Manila alone by year-end,” closes Phelan.With the fresh funds, WeClean is growing its pickup and delivery vertical and is starting to franchise its laundry business concept, which Barroso said has already generated a lot of interest. “With our aim to bring our laundry shops closer to Filipinos, we are hoping that we will be able to help our customers realize the true benefit of trusting a reliable laundromat like ours. We want to offer direct communication at a time when laundry has really become part and parcel of everyday life,” muses Phelan.Īvailable on the AppStore and Google Play, the WeClean App will surely help more consumers find laundry services convenient even during their busiest days. “This platform will up the notch when it comes to listening to and providing our customers what they really need – time-saving accessible laundry services at the tip of their fingers. The app is equipped with features such as the ability to book a pickup and delivery service as well as pre-book a laundry branch drop-off with certain customer specifications such as the type of clothing, type of fold, type of wash/dry, how much soap or fabric conditioner to be used, etc. ![]() On April 1, WeClean will be officially making available its mobile application aiming to make customer experience better, more convenient, and accessible to more Filipinos in Metro Manila. The team is also simultaneously working on the launch of the WeClean Mobile App. While plans have not been set in stone yet, WeClean is optimistic that its growth plan will take them to places where the laundry business is in demand. And in a few months after successfully opening in Bulacan, Cavite, Laguna and Palawan, we are eyeing to open our first branches in other SEA countries like Thailand, Malaysia, and Indonesia,” Patiño adds. These nearby provinces are key to our business growth plan. “We look at residential areas with a lot of traffic such as those within distance from high-rise condominiums or barangays where people cannot afford to have washing machines at home. ![]() The company manages and operates 63 branches to date and plans to expand outside of Metro Manila with branches in nearby provinces such as Bulacan, Cavite, Laguna, and even as far as Palawan. On Expanding Across the Country and Region This shows them that we mean serious business,” adds Patiño. “At WeClean, we make decisions quickly as making them an offer within 24 hours of receiving their financial reports. WeClean also prides itself in being efficient and decisive. “The way we secure and close deals to purchase small players in the laundromat industry is by talking to strategically located businesses who want to change their core business or retire from running their operations,” says Alfonso Bigeriego Patiño, Chief Executive Officer of WeClean. In its mission to expand, WeClean identified strategically located existing brick and mortar businesses whose owners were looking for a change. However, last year showed us great promise as the demand for laundry businesses grew as it was an essential service most Filipinos need,” adds Phelan. At the beginning of the pandemic, we closed some branches that were losing money and reallocated the machines to better-performing ones. “Sales were greatly affected but we were also able to buy competitors at very low costs. The team behind WeClean claims that the COVID-19 pandemic, though a challenge, actually also presented them with opportunities. On Overcoming the Effects of the Pandemic It is a massive goal for us to be able to stay true to our plans and move forward with our plans for the year,” shares Ignacio Phelan, Chief Operating Officer of WeClean. “The funding we secured last year has really fueled us to aggressively expand our operations to open and manage 500 laundromats not just in nearby provinces but across the whole of the Philippines in the next three years. 12/24/2023 0 Comments Super mario enemiesThe games all typically share common enemies. Other main and supporting antagonists appear as an additional hindrance to the main character, such as the Koopalings. Some games have supporting protagonists that aid the main character, such as Professor E. Throughout each series of games, numerous characters have been introduced, and have since become recurring. introduced Toad alongside numerous enemies, with Bowser and Princess Peach replacing Donkey Kong and Pauline. introduced Mario's fraternal twin Luigi, and Super Mario Bros. Due to the critical and commercial success of Donkey Kong when it was released in July 1981, Mario reappeared in Mario Bros. Unable to obtain licensing rights for the characters, Miyamoto made later changes to their appearances and personalities, such as making them more lighthearted in tone. Designed by Japanese video game designer Shigeru Miyamoto they were built off the base of characters from Popeye. Many characters have goals or plot arcs that vary from series to series for example, the Luigi's Mansion games focus on Luigi ridding a haunted building of ghosts, while Wario stars in games that center around his greed and desire for money and treasure.Ĭharacter roots begin with Donkey Kong where Mario, Donkey Kong, and Pauline originate. Games in the Mario franchise primarily revolve around the protagonist Super Mario and often involve the trope of Bowser as the antagonist kidnapping Princess Peach, with Mario then rescuing her. While Nintendo is usually the developer and publisher of games in the franchise, various series are developed by third-party companies, such as Hudson Soft and Intelligent Systems. The Mario franchise is a video game series by Nintendo. ![]() A handful of characters in the Mario franchise: Goomba, Wario, Daisy, Toad, Donkey Kong, Peach, Mario, Bowser, Luigi, Yoshi, Rosalina, Waluigi, Boo and Koopa Troopas. 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